製品の概要

  • 製品名Anti-Synaptophysin antibody [SP15]
    Synaptophysin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [SP15] to Synaptophysin
  • 特異性Ab11105 recognises an antigen which appears to be identical to the human synaptic vesicle protein synaptophysin. It reacts with synaptophysin expressed in CHO cells (Honer WG et al. 1993); (Wakabayashi K et al. 1994).
  • アプリケーション適用あり: IHC-P, ELISA, WBmore details
  • 種交差性
    交差種: Rat, Hamster, Human, Pig
  • 免疫原

    Crude human synaptic immunoprecipitate.

  • ポジティブ・コントロール
    • Brain.
  • 特記事項This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 精製度Purified IgM
  • 特記事項(精製)Purified IgM prepared by gel filtration from tissue culture supernatant.
  • ポリ/モノモノクローナル
  • クローン名SP15
  • ミエローマNS0
  • アイソタイプIgM
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab11105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/500 - 1/1000.
ELISA Use at an assay dependent dilution.
WB 1/500. Predicted molecular weight: 37.6 kDa.

ターゲット情報

  • 機能Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
  • 組織特異性Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
  • 関連疾患Mental retardation, X-linked, SYP-related
  • 配列類似性Belongs to the synaptophysin/synaptobrevin family.
    Contains 1 MARVEL domain.
  • ドメインThe calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
  • 翻訳後修飾Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • 細胞内局在Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Major synaptic vesicle protein p38 antibody
    • MRX96 antibody
    • MRXSYP antibody
    • Syn p38 antibody
    • Synaptophysin antibody
    • Syp antibody
    • SYPH antibody
    • SYPH_HUMAN antibody
    • SypI antibody
    see all

Anti-Synaptophysin antibody [SP15] 画像

  • ab11105, at a dilution of 1/25, staining Synaptophysin in human pancreas section by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-Synaptophysin antibody [SP15] (ab11105) 使用論文

This product has been referenced in:
  • Micheva KD & Smith SJ Array tomography: a new tool for imaging the molecular architecture and ultrastructure of neural circuits. Neuron 55:25-36 (2007). IHC . Read more (PubMed: 17610815) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry. Synaptophysin antibodies ab11105 and ab24729 are derived from two different monoclonal clones: [SP15] and [SP17]. They were raised against different immunogens and recognise different epitopes. Both antisera have als...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"