製品の概要

  • 製品名Anti-Synaptophysin antibody [4E206]
    Synaptophysin 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [4E206] to Synaptophysin
  • アプリケーション適用あり: WB, IP, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Cow, Human
  • 免疫原

    Synaptic vesicle-containing fractions immunoprecipitated from human brain homogenates using anti-human Synaptophysin monoclonal antibodies.

  • ポジティブ・コントロール
    • Mouse and rat brain tissue extract. No reactivity was detected in mouse liver extracts.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab18008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000. Detects a band of approximately 38 kDa.
IP 1/100.
IHC-P Use at an assay dependent dilution.

ターゲット情報

  • 機能Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.
  • 組織特異性Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.
  • 関連疾患Mental retardation, X-linked, SYP-related
  • 配列類似性Belongs to the synaptophysin/synaptobrevin family.
    Contains 1 MARVEL domain.
  • ドメインThe calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.
  • 翻訳後修飾Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • 細胞内局在Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Major synaptic vesicle protein p38 antibody
    • MRX96 antibody
    • MRXSYP antibody
    • Syn p38 antibody
    • Synaptophysin antibody
    • Syp antibody
    • SYPH antibody
    • SYPH_HUMAN antibody
    • SypI antibody
    see all

Anti-Synaptophysin antibody [4E206] (ab18008) 使用論文

This product has been referenced in:
  • Lee J  et al. Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma. Cancer Res 70:10131-40 (2010). Read more (PubMed: 21159635) »
  • Winden KD  et al. The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol 5:291 (2009). WB ; Mouse . Read more (PubMed: 19638972) »

See all 4 Publications for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Rat Tissue lysate - other (Cortex)
Loading amount 50 µg
Specification Cortex
Blocking step Milk as blocking agent for 45 minute(s) · Concentration: 5%
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投稿 Jan 15 2007

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"