Anti-Synapsin I (phospho S549) 抗体 (ab119370)

製品の概要

  • 製品名
    Anti-Synapsin I (phospho S549) antibody
    Synapsin I 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Synapsin I (phospho S549)
  • 特異性
    ab119370 detects endogenous levels of Synapsin I only when phosphorylated at Serine 549.
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to a sequence surrounding phosphorylation site Serine 549 (PASPPS) of Rat Synapsin I (P09951).

  • ポジティブ・コントロール
    • Rat and Mouse Brain tissue.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • バッファー
    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non phosphospecific antibodies were removed by chromatography using non-phosphopeptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab119370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Predicted molecular weight: 74 kDa. Incubate membrane with diluted antibody in 5% non-fat milk, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight.

ターゲット情報

  • 機能
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • 関連疾患
    Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
  • 配列類似性
    Belongs to the synapsin family.
  • 翻訳後修飾
    Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在
    Cell junction > synapse. Golgi apparatus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Brain protein 4.1 antibody
    • SYN 1 antibody
    • SYN 1a antibody
    • SYN 1b antibody
    • SYN I antibody
    • SYN1 antibody
    • SYN1_HUMAN antibody
    • SYN1a antibody
    • SYN1b antibody
    • Synapsin 1 antibody
    • Synapsin I antibody
    • Synapsin-1 antibody
    • Synapsin1 antibody
    • SynapsinI antibody
    • SYNI antibody
    see all

画像

  • All lanes : Anti-Synapsin I (phospho S549) antibody (ab119370) at 1/1000 dilution

    Lane 1 : Rat Brain lysate.
    Lane 2 : Mouse Brain lysate.


    Predicted band size : 74 kDa

プロトコール

参考文献

ab119370 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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