製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to Synapsin I
  • アプリケーション
    適用あり: IHC-P, ELISAmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat
  • 免疫原

    Synthetic non-phosphopeptide derived from human Synapsin 1 around the phosphorylation site of serine 62 (V-A-SP-P-A).

  • ポジティブ・コントロール
    • Human brain tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab59268 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use at an assay dependent concentration.
ELISA 1/5000.

ターゲット情報

  • 機能
    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
  • 関連疾患
    Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
  • 配列類似性
    Belongs to the synapsin family.
  • 翻訳後修飾
    Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在
    Cell junction > synapse. Golgi apparatus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Brain protein 4.1 antibody
    • SYN 1 antibody
    • SYN 1a antibody
    • SYN 1b antibody
    • SYN I antibody
    • SYN1 antibody
    • SYN1_HUMAN antibody
    • SYN1a antibody
    • SYN1b antibody
    • Synapsin 1 antibody
    • Synapsin I antibody
    • Synapsin-1 antibody
    • Synapsin1 antibody
    • SynapsinI antibody
    • SYNI antibody
    see all

画像

  • Immunohistochemical analysis of paraffin-embedded human brain tissue using ab59268 at a dilution of 1/50-1/100. Left hand image - without immunising peptide; right hand image - with immunising peptide.

プロトコール

参考文献

This product has been referenced in:
  • Kazemi M  et al. Modulation of axonal sprouting along rostro-caudal axis of dorsal hippocampus and no neuronal survival in parahippocampal cortices by long-term post-lesion melatonin administration in lithium-pilocarpine model of temporal lobe epilepsy. Anat Cell Biol 49:21-33 (2016). IF . Read more (PubMed: 27051565) »

See 1 Publication for this product

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