製品の概要

  • 製品名
  • 製品の詳細
    Mouse polyclonal to SWAP70
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length Human SWAP70 (NP_055870.2, amino acids 1-585).

  • ポジティブ・コントロール
    • Human spleen tissue lysate, HepG2 cell lysate, SWAP70 transfected 293T cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab89605 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 69 kDa.

ターゲット情報

  • 機能
    Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
  • 組織特異性
    Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
  • 配列類似性
    Contains 1 PH domain.
  • ドメイン
    The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
  • 翻訳後修飾
    Tyrosine-phosphorylated.
  • 細胞内局在
    Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
  • Information by UniProt
  • 参照データベース
  • 別名
    • KIAA0640 antibody
    • 70kDa antibody
    • AV235546 antibody
    • FLJ39540 antibody
    • HSPC321 antibody
    • SWA 70 protein antibody
    • SWAP 70 antibody
    • SWAP switching B-cell complex 70kDa subunit antibody
    • SWAP-70 antibody
    • SWAP70 antibody
    • Switch associated protein 70 antibody
    • Switch-associated protein 70 antibody
    • SWP70_HUMAN antibody
    see all

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プロトコール

参考文献

ab89605 has not yet been referenced specifically in any publications.

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