製品の概要

  • 製品名Anti-SWAP70 antibody
    SWAP70 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SWAP70
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Cow, Dog, Chimpanzee
  • 免疫原

    Synthetic peptide, sequence taken from within amino acids 300-350 of human SWAP-70.

  • ポジティブ・コントロール
    • Daudi cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab47084 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 69 kDa).

ターゲット情報

  • 機能Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
  • 組織特異性Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
  • 配列類似性Contains 1 PH domain.
  • ドメインThe PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
  • 翻訳後修飾Tyrosine-phosphorylated.
  • 細胞内局在Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
  • Information by UniProt
  • 参照データベース
  • 別名
    • KIAA0640 antibody
    • 70kDa antibody
    • AV235546 antibody
    • FLJ39540 antibody
    • HSPC321 antibody
    • SWA 70 protein antibody
    • SWAP 70 antibody
    • SWAP switching B-cell complex 70kDa subunit antibody
    • SWAP-70 antibody
    • SWAP70 antibody
    • Switch associated protein 70 antibody
    • Switch-associated protein 70 antibody
    • SWP70_HUMAN antibody
    see all

Anti-SWAP70 antibody 画像

  • Anti-SWAP70 antibody (ab47084) at 2 µg/ml + Daudi cell lysate

    Predicted band size : 69 kDa
    Observed band size : 65 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

Anti-SWAP70 antibody (ab47084) 使用論文

ab47084 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab47084.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"