製品の概要

  • 製品名Anti-STXBP2 antibody
    STXBP2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to STXBP2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 439-469 of Human STXBP2 (UniProt ID: Q15833).

  • ポジティブ・コントロール
    • 293 cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab123679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 66 kDa.

ターゲット情報

  • 機能Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
  • 組織特異性Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
  • 関連疾患Defects in STXBP2 are the cause of hemophagocytic lymphohistiocytosis familial type 5 (FHL5) [MIM:613101]. FHL5 is rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
  • 配列類似性Belongs to the STXBP/unc-18/SEC1 family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FHL5 antibody
    • Hunc18b antibody
    • MUNC18 2 antibody
    • pp10122 antibody
    • Protein unc-18 homolog 2 antibody
    • Protein unc-18 homolog B antibody
    • STXB2_HUMAN antibody
    • Stxbp2 antibody
    • syntaxin binding protein 2 antibody
    • Syntaxin-binding protein 2 antibody
    • Unc-18B antibody
    • UNC18 2 antibody
    • Unc18-2 antibody
    • UNC18B antibody
    see all

Anti-STXBP2 antibody 画像

  • Anti-STXBP2 antibody (ab123679) at 1/100 dilution + 293 cell lysate at 35 µg

    Predicted band size : 66 kDa

Anti-STXBP2 antibody (ab123679) 使用論文

ab123679 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab123679.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"