Anti-STXBP2 抗体 (ab103976)


  • 製品名Anti-STXBP2 antibody
    STXBP2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to STXBP2
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 310-524 of Human STXBP2 (AAH02869).

  • ポジティブ・コントロール
    • A431 and HepG2 cell lines. H1299 and HeLa whole cell lysate.




Our Abpromise guarantee covers the use of ab103976 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 66 kDa.
ICC/IF 1/200. Use with paraformaldehyde fixed cells.


  • 機能Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
  • 組織特異性Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
  • 関連疾患Defects in STXBP2 are the cause of hemophagocytic lymphohistiocytosis familial type 5 (FHL5) [MIM:613101]. FHL5 is rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
  • 配列類似性Belongs to the STXBP/unc-18/SEC1 family.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FHL5 antibody
    • Hunc18b antibody
    • MUNC18 2 antibody
    • pp10122 antibody
    • Protein unc-18 homolog 2 antibody
    • Protein unc-18 homolog B antibody
    • STXB2_HUMAN antibody
    • Stxbp2 antibody
    • syntaxin binding protein 2 antibody
    • Syntaxin-binding protein 2 antibody
    • Unc-18B antibody
    • UNC18 2 antibody
    • Unc18-2 antibody
    • UNC18B antibody
    see all

Anti-STXBP2 antibody 画像

  • All lanes : Anti-STXBP2 antibody (ab103976) at 1/1000 dilution

    Lane 1 : H1299 whole cell lysate
    Lane 2 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 66 kDa
  • ab103976 (1/200) staining STXBP2 in HeLa cells (green). Cells were fixed in paraformaldehyde, permeabilised in 0.5% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (red). For further experimental details please refer to Abreview.

    See Abreview

Anti-STXBP2 antibody (ab103976) 使用論文

ab103976 has not yet been referenced specifically in any publications.

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Unfortunately ab103976 has never been tested in Flow Cytometry assays. It doesn’t mean it won’t work in this application, but we don’t have data to support it.

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Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (HeLa)
Specification HeLa
Fixative Paraformaldehyde
Permeabilization Yes - 0.5% Triton-X100 in PBS

Dr. Kirk Mcmanus

Verified customer

投稿 Apr 24 2012