製品の概要

  • 製品名Anti-STUB1 antibody
    STUB1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to STUB1
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Chimpanzee
  • 免疫原

    Synthetic peptide:

    DAFISENGWVEDY

    , corresponding to C terminal amino acids 291-303 of Human STUB1

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab2482 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
  • 追加情報Peptide ELISA: Antibody detection limit dilution 1:32,000.
    WB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 35 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.
    • 組織特異性Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
    • パスウェイProtein modification; protein ubiquitination.
    • 配列類似性Contains 3 TPR repeats.
      Contains 1 U-box domain.
    • ドメインThe TPR domain is essential for ubiquitination mediated by UBE2D1.
    • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
      Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2.
    • 細胞内局在Cytoplasm.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Antigen NY CO 7 antibody
      • Antigen NY-CO-7 antibody
      • C terminus of Hsp70-interacting protein antibody
      • Carboxy terminus of Hsp70 interacting protein antibody
      • Carboxy terminus of Hsp70-interacting protein antibody
      • Carboxy terminus of Hsp70p interacting protein antibody
      • CHIP antibody
      • CHIP_HUMAN antibody
      • CLL associated antigen KW 8 antibody
      • CLL-associated antigen KW-8 antibody
      • E3 ubiquitin protein ligase CHIP antibody
      • E3 ubiquitin-protein ligase CHIP antibody
      • Heat shock protein A binding protein 2 (c terminal) antibody
      • HSPABP2 antibody
      • NY CO 7 antibody
      • PP1131 antibody
      • SDCCAG7 antibody
      • Serologically defined colon cancer antigen 7 antibody
      • STIP1 homology and U Box containing protein 1 antibody
      • STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase antibody
      • STIP1 homology and U box-containing protein 1 antibody
      • STUB 1 antibody
      • STUB1 antibody
      • UBOX 1 antibody
      • UBOX1 antibody
      see all

    Anti-STUB1 antibody 画像

    • Anti-STUB1 antibody (ab2482) at 1 µg/ml + Human Heart lysate (RIPA buffer, 35ug total protein per lane).

      Predicted band size : 35 kDa

    Anti-STUB1 antibody (ab2482) 使用論文

    This product has been referenced in:
    • Bento CF  et al. Methylglyoxal alters the function and stability of critical components of the protein quality control. PLoS One 5:e13007 (2010). WB ; Human . Read more (PubMed: 20885985) »
    • Bento CF  et al. The chaperone-dependent ubiquitin ligase CHIP targets HIF-1a for degradation in the presence of methylglyoxal. PLoS One 5:e15062 (2010). WB ; Human . Read more (PubMed: 21124777) »

    See all 2 Publications for this product

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