Strychnine hydrochloride, Glycine antagonist (ab120416)
Key features and details
- Glycine antagonist
- CAS Number: 1421-86-9
- Soluble in water to 50 mM
- Form / State: Solid
- Source: Strychnos sp.
製品の概要
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製品名
Strychnine hydrochloride, Glycine antagonist -
製品の詳細
Glycine antagonist -
生理活性の詳細
Competitive glycine receptor antagonist. Convulsant. Also antagonist at α7 receptors and α4β2 nicotinic receptors.
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CAS 番号
1421-86-9 -
構造式
製品の特性
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体系名
Strychnidin-10-one hydrochloride -
分子量
370.87 -
分子式
C21H22N2O2.HCl -
PubChem 登録番号
16219987 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cl.O=C2C[C@@H]7OCC=C6CN4CC[C@@]53c1ccccc1N2C3[C@H]7[C@H]6C[C@H]45 -
由来
Strychnos sp.
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (27)
ab120416 は 27 報の論文で使用されています。
- Martín-de-Saavedra MD et al. Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2. Neuron 110:627-643.e9 (2022). PubMed: 34921780
- Huang DF et al. Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons. Proc Natl Acad Sci U S A 119:e2203632119 (2022). PubMed: 35951651
- Guo C et al. Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex. Elife 10:N/A (2021). PubMed: 34369877
- Khan MM & Regehr WG Loss of Doc2b does not influence transmission at Purkinje cell to deep nuclei synapses under physiological conditions. Elife 9:N/A (2020). PubMed: 32347796
- St Laurent R et al. Periaqueductal Gray and Rostromedial Tegmental Inhibitory Afferents to VTA Have Distinct Synaptic Plasticity and Opiate Sensitivity. Neuron 106:624-636.e4 (2020). PubMed: 32191871