製品の概要

  • 製品名Anti-Stromal interaction molecule 1 antibody
    Stromal interaction molecule 1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Stromal interaction molecule 1
  • 特異性At least two isoforms of Human STIM1 protein are known to exist. ab106531 will detect only the larger of the two isoforms. This STIM1 antibody is predicted to have no cross-reactivity to STIM2.
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to a region near the carboxy terminus of Human Stromal interaction molecule 1.

  • ポジティブ・コントロール
    • Human spleen tissue; Mouse thymus tissue lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab106531 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 77 kDa.
ELISA 1/10000 - 1/40000.
IHC-P Use a concentration of 2.5 µg/ml.

ターゲット情報

  • 機能Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
  • 組織特異性Ubiquitously expressed in various human primary cells and tumor cell lines.
  • 関連疾患Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) [MIM:612783]. IDTICED2 is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels. Additional features include thrombocytopenia, autoimmune hemolytic anemia, non-progressive myopathy, partial iris hypoplasia, hepatosplenomegaly and defective enamel dentition.
  • 配列類似性Contains 1 EF-hand domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • ドメインThe microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.
  • 翻訳後修飾Glycosylation is required for cell surface expression.
    Phosphorylated predominantly on Ser residues.
  • 細胞内局在Cell membrane. Endoplasmic reticulum membrane. Cytoplasm > cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium. Associated with the microtubule network at the growing distal tip of microtubules.
  • Information by UniProt
  • 参照データベース
  • 別名
    • D11S4896E antibody
    • GOK antibody
    • OTTHUMP00000164512 antibody
    • OTTHUMP00000229140 antibody
    • OTTHUMP00000230742 antibody
    • SIM antibody
    • STIM 1 antibody
    • STIM1 antibody
    • Stim1 stromal interaction molecule 1 antibody
    • STIM1_HUMAN antibody
    • STIM1L antibody
    • Stromal interaction molecule 1 antibody
    see all

Anti-Stromal interaction molecule 1 antibody 画像

  • Lane 1 : Anti-Stromal interaction molecule 1 antibody (ab106531) at 1 µg/ml
    Lane 2 : Anti-Stromal interaction molecule 1 antibody (ab106531) at 2 µg/ml

    Lane 1 : Mouse thymus tissue lysate
    Lane 2 : Mouse thymus tissue lysate


    Predicted band size : 77 kDa
  • ab106531, at 2.5 µg/ml, staining STIM1 in Human spleen tissue by Immunohistochemistry.

Anti-Stromal interaction molecule 1 antibody (ab106531) 使用論文

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