製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to STEAP1
  • 特異性
    This antibody reacts predominantly with STEAP. Ab3679 can be used as a plasma marker for prostate cancer cells
  • アプリケーション
    適用あり: WB, IP, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    WKMKPRRNLEEDDYL

    , corresponding to amino acids 14-28 of Human STEAP.

  • ポジティブ・コントロール
    • WB: A431 cell lysate
  • 特記事項


    Prostate cancer is the most frequently diagnosed cancer and is the second leading cause of cancer-related deaths in American men. Although the early serum detection of prostate-specific antigen (PSA) plays important roles in early diagnosis, it may not distinguish prostate cancer from benign diseases. Recently, a novel protein, which contains 339 amino acids, named STEAP (six transmembrane epithelial antigen of the prostate), was identified in advanced prostate cancer. STEAP is unique among the currently known prostate cancer markers because of its putative secondary structure, from which one may predict that it functions as a potential channel protein. STEAP is strongly expressed in advanced prostate cancer and some extent expression in other cancers, such as colon and ovarian cancer cell lines.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファー
    PBS with 0.02% sodium azide
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 一次抗体 備考
    Prostate cancer is the most frequently diagnosed cancer and is the second leading cause of cancer-related deaths in American men. Although the early serum detection of prostate-specific antigen (PSA) plays important roles in early diagnosis, it may not distinguish prostate cancer from benign diseases. Recently, a novel protein, which contains 339 amino acids, named STEAP (six transmembrane epithelial antigen of the prostate), was identified in advanced prostate cancer. STEAP is unique among the currently known prostate cancer markers because of its putative secondary structure, from which one may predict that it functions as a potential channel protein. STEAP is strongly expressed in advanced prostate cancer and some extent expression in other cancers, such as colon and ovarian cancer cell lines.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab3679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 38 kDa).
IP Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

ターゲット情報

  • 機能
    Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
  • 組織特異性
    Ubiquitously expressed. Highly expressed in prostate tumors.
  • 配列類似性
    Belongs to the STEAP family.
    Contains 1 ferric oxidoreductase domain.
  • 細胞内局在
    Endosome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 2410007B19Rik antibody
    • EC 1.16.1.- antibody
    • Metalloreductase STEAP1 antibody
    • MGC19484 antibody
    • PRSS 24 antibody
    • PRSS24 antibody
    • Six transmembrane epithelial antigen of prostate antibody
    • Six transmembrane epithelial antigen of the prostate 1 antibody
    • Six transmembrane epithelial antigen of the prostate antibody
    • Six-transmembrane epithelial antigen of prostate 1 antibody
    • STEA1_HUMAN antibody
    • STEAP 1 antibody
    • Steap antibody
    • STEAP1 antibody
    see all

画像



  • Predicted band size : 38 kDa


    A431 cell lysate probed with anti-STEAP (ab3679) at 1 microgram/ml

参考文献

ab3679 has not yet been referenced specifically in any publications.

レビューと Q&A

Thank you for your enquiry and your patience. We are very sorry that the customer is having problem with this product. We have read through the forwarded protocol and it seems to be fine. After careful consideration, we offer a credit note. W...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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