Anti-Stathmin 1 (phospho S16) 抗体 (ab47328)
Key features and details
- Rabbit polyclonal to Stathmin 1 (phospho S16)
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Stathmin 1 (phospho S16) antibody
Stathmin 1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Stathmin 1 (phospho S16) -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human Stathmin 1 aa 1-100 (phospho S16). synthesized phosphopeptide derived from human Stathmin 1 around the phosphorylation site of serine 16 (R-A-SP-G-Q)
Database link: P16949 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol, 0.87% Sodium chloride -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
The antibody was affinity-purified using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab47328の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/50 - 1/100.
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特記事項 |
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IHC-P
1/50 - 1/100. |
ターゲット情報
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機能
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. -
組織特異性
Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. -
配列類似性
Belongs to the stathmin family.
Contains 1 SLD (stathmin-like) domain. -
翻訳後修飾
Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. -
細胞内局在
Cytoplasm > cytoskeleton. - Information by UniProt
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参照データベース
- Entrez Gene: 3925 Human
- Omim: 151442 Human
- SwissProt: P16949 Human
- Unigene: 209983 Human
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別名
- C1orf215 antibody
- Lag antibody
- LAP 18 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab47328 は 9 報の論文で使用されています。
- Funke L et al. NTRK1/TrkA Signaling in Neuroblastoma Cells Induces Nuclear Reorganization and Intra-Nuclear Aggregation of Lamin A/C. Cancers (Basel) 13:N/A (2021). PubMed: 34771457
- You M et al. Perinatal exposure to nonylphenol impairs dendritic outgrowth of cerebellar Purkinje cells in progeny. Chemosphere 211:758-766 (2018). PubMed: 30099160
- Chen X et al. The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro. Int J Mol Med 40:235-242 (2017). PubMed: 28534969
- Alesi GN et al. RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis. Oncogene 35:5412-5421 (2016). PubMed: 27041561
- Kempf SJ et al. An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model. Oncotarget 7:33627-48 (2016). PubMed: 27144524
- Zhang L et al. Increased stathmin expression strengthens fear conditioning in epileptic rats. Biomed Rep 3:28-32 (2015). PubMed: 25469242
- Yip YY et al. cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress. J Biol Chem 289:2157-69 (2014). PubMed: 24302736
- Tian X et al. Novel role of stathmin in microtubule-dependent control of endothelial permeability. FASEB J 26:3862-74 (2012). PubMed: 22700873
- Higuero AM et al. Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development. J Biol Chem 285:1343-57 (2010). WB, ICC/IF ; Rat . PubMed: 19903810