Anti-STAT2 抗体 [Y141] (ab32367)

製品の概要

• 製品名
  Anti-STAT2 antibody [Y141]
  STAT2 一次抗体 製品一覧
• 製品の詳細
  Rabbit monoclonal [Y141] to STAT2
• 特異性
  This antibody detects both long and short forms of STAT2.
• アプリケーション
  適用あり: WB, ICC, IHC-Pmore details
  適用なし: Flow Cyt or IP
• 種交差性
  交差種: Mouse, Rat, Human
  
• 免疫原

  A synthetic peptide corresponding to residues near N-terminus of human Stat-2.

• ポジティブ･コントロール
  • K562 cell lysate and human thyroid cancer
• 特記事項

  This product is a recombinant rabbit monoclonal antibody.

   

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Concentration information loading...
• 精製度
  IgG fraction
• ポリ/モノ
  モノクローナル
• クローン名
  Y141
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • STATs

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • STATs

関連製品

• Positive Controls
  • K562 whole cell lysate (ab7911)

アプリケーション

ターゲット情報

• 機能
  Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
• 配列類似性
  Belongs to the transcription factor STAT family.
  Contains 1 SH2 domain.
• 翻訳後修飾
  Tyrosine phosphorylated in response to IFN-alpha.
• 細胞内局在
  Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.

• Target information above from: UniProt accession P52630 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 6773 Human
  • Entrez Gene: 20847 Mouse
  • Entrez Gene: 288774 Rat
  • Omim: 600556 Human
  • SwissProt: P52630 Human
  • SwissProt: Q9WVL2 Mouse
  • Unigene: 530595 Human
  • Unigene: 293120 Mouse

  • Unigene: 471333 Mouse
  • Unigene: 24237 Rat

  see all
• 別名
  • Homo sapiens interferon alpha induced transcriptional activator antibody
  • interferon alpha induced transcriptional activator antibody
  • ISGF 3 antibody

  • ISGF3 antibody
  • MGC59816 antibody
  • P113 antibody
  • signal transducer and activator of transcription 2 113kD antibody
  • Signal transducer and activator of transcription 2 antibody
  • STAT113 antibody
  • Stat2 antibody
  • STAT2_HUMAN antibody

  see all