製品の概要

  • 製品名
    Anti-STAT2 antibody [19G8.H2.H6]
    STAT2 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [19G8.H2.H6] to STAT2
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A synthetic peptide corresponding to residues near the carboxy terminus of mouse STAT2 protein.

  • ポジティブ・コントロール
    • HeLa whole cell lysate; Human skin tissue (squamous epithelium).
  • 特記事項
    Expiration date is one year from date of opening.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab106094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 98 kDa.
IHC-P Use a concentration of 2.5 µg/ml.

ターゲット情報

  • 機能
    Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • 配列類似性
    Belongs to the transcription factor STAT family.
    Contains 1 SH2 domain.
  • 翻訳後修飾
    Tyrosine phosphorylated in response to IFN-alpha.
  • 細胞内局在
    Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Homo sapiens interferon alpha induced transcriptional activator antibody
    • interferon alpha induced transcriptional activator antibody
    • ISGF 3 antibody
    • ISGF3 antibody
    • MGC59816 antibody
    • P113 antibody
    • signal transducer and activator of transcription 2 113kD antibody
    • Signal transducer and activator of transcription 2 antibody
    • STAT113 antibody
    • Stat2 antibody
    • STAT2_HUMAN antibody
    see all

画像

  • Anti-STAT2 antibody [19G8.H2.H6] (ab106094) at 1/1000 dilution + HeLa whole cell lysate at 1 µg

    Predicted band size : 98 kDa
  • ab106094 at 2.5µg/ml staining STAT2 in Formalin fixed, Paraffin-embedded Human Skin (squamous epithelium) by Immunohistochemistry. Note: moderate to strong nuclear and faint to moderate cytoplasmic staining.
    The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.

参考文献

ab106094 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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