製品の概要

  • 製品名Anti-STAM1 antibody
    STAM1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to STAM1
  • アプリケーション適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rabbit, Guinea pig, Cow, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 400-450 of Human STAM1 (NP_003464.1).

  • ポジティブ・コントロール
    • HeLa whole cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab117817 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP Use at 2-10 µg/mg of lysate.
  • 追加情報Is unsuitable for WB.
  • ターゲット情報

    • 機能Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
    • 組織特異性Ubiquitously expressed.
    • 配列類似性Belongs to the STAM family.
      Contains 1 ITAM domain.
      Contains 1 SH3 domain.
      Contains 1 UIM (ubiquitin-interacting motif) repeat.
      Contains 1 VHS domain.
    • 翻訳後修飾Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
    • 細胞内局在Cytoplasm. Early endosome membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • HSE1 homolog antibody
      • Signal transducing adapter molecule 1 antibody
      • signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antibody
      • STAM antibody
      • STAM-1 antibody
      • STAM1_HUMAN antibody
      see all

    Anti-STAM1 antibody 画像

    • Detection of Human STAM1 in Immunoprecipitates of Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells using ab117817 at 6 µg/mg of lysate. Subsequent WB detection was done using an other anti Human STAM1 antibody.
      Detection: Chemiluminescence with an exposure time of 10 seconds.

    Anti-STAM1 antibody (ab117817) 使用論文

    ab117817 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab117817.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"