製品の概要

  • 製品名Anti-Stabilin 2 antibody
  • 製品の詳細
    Rabbit polyclonal to Stabilin 2
  • アプリケーション適用あり: IHC-P, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 1203-1334 of Human Stabilin 2. (Q8WWQ8)

  • ポジティブ・コントロール
    • Human spleen tissue; U 251 MG cells.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab121893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100

ターゲット情報

  • 機能Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.
  • 組織特異性Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
  • 配列類似性Contains 17 EGF-like domains.
    Contains 7 FAS1 domains.
    Contains 2 laminin EGF-like domains.
    Contains 1 Link domain.
  • ドメインRecognizes phosphatidyl serine via its epidermal growth factor-like domains.
  • 翻訳後修飾Glycosylated.
    Proteolytically processed to yield a 190 kDa protein.
  • 細胞内局在Cell membrane. Cytoplasm. Only a small amount appears to be present at the cell surface.
  • Information by UniProt
  • 参照データベース
  • 別名
    • 190 kDa form stabilin-2 antibody
    • 190 kDa hyaluronan receptor for endocytosis antibody
    • EGF-like antibody
    • FAS1 EGF-like and X-link domain-containing adhesion molecule 2 antibody
    • Fasciclin antibody
    • FEEL-2 antibody
    • FEEL2 antibody
    • FELL antibody
    • FEX2 antibody
    • HARE antibody
    • Hyaluronan receptor for endocytosis antibody
    • laminin-type EGF-like and link domain-containing scavenger receptor 2 antibody
    • link domain-containing scavenger receptor 2 antibody
    • STAB-2 antibody
    • Stab2 antibody
    • STAB2_HUMAN antibody
    see all

Anti-Stabilin 2 antibody 画像

  • ab121893 at 1/200 dilution staining Stabilin 2 in Paraffin-embedded Human Spleen tissue by Immunohistochemistry.
  • ab128931 at 4 µg/ml staining Stabilin 2 in PFA/Triton X-100 fixed/permeabilized U 251 MG cells by Immunofluorescence (green).

Anti-Stabilin 2 antibody (ab121893) 使用論文

ab121893 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"