機能Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin.
組織特異性Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain.
ドメインBoth the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for interaction with SSX2.
細胞内局在Cell junction > adherens junction. Nucleus. Not found at cell-matrix AJs.
Detection of SSX2IP by Western Blot of Immunprecipitate.
ab117754 at 1µg/ml staining SSX2IP in 293T whole cell lysate immunoprecipitated using ab117754 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection: Chemiluminescence with exposure time of 30 seconds.
Western blot - Anti-SSX2IP antibody (ab117754)
All lanes : Anti-SSX2IP antibody (ab117754) at 0.4 µg/ml
Lane 1 : 293T cell line lysate at 50 µg Lane 2 : 293T cell line lysate at 15 µg Lane 3 : Jurkat cell line lysate at 50 µg Lane 4 : HeLa cell line lysate at 50 µg
Developed using the ECL technique
Predicted band size : 71 kDa
Exposure time : 3 minutes
Anti-SSX2IP antibody (ab117754) 使用論文
has not yet been referenced specifically in any publications.