Anti-SSH3BP1 (phospho Y435) 抗体 [EP3954] (ab109395)


  • 製品名Anti-SSH3BP1 (phospho Y435) antibody [EP3954]
    SSH3BP1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EP3954] to SSH3BP1 (phospho Y435)
  • 特異性ab109395 only detects SSH3BP1 phosphorylated at tyrosine 435.
  • アプリケーション適用あり: WB, IP, ICC, Flow Cytmore details
    適用なし: IHC-P
  • 種交差性
    交差種: Human
  • 免疫原

    A phospho specific peptide corresponding to residues surrounding tyrosine 435 of Human SSH3BP1.

  • ポジティブ・コントロール
    • Jurkat cell lysate treated with pervanadate.
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.


    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.



Our Abpromise guarantee covers the use of ab109395 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/10000 - 1/50000. Predicted molecular weight: 55 kDa.
IP 1/10 - 1/100.
ICC 1/250 - 1/500.
Flow Cyt 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

  • 追加情報Is unsuitable for IHC-P.
  • ターゲット情報

    • 機能May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.
    • 組織特異性Widely expressed, with highest expression in brain.
    • 関連疾患Note=A chromosomal aberration involving ABI1 is a cause of acute leukemias. Translocation t(10;11)(p11.2;q23) with MLL. ABI1 isoform 2 was found to be present in acute leukemia MLL-ABI1 fusion transcript.
    • 配列類似性Belongs to the ABI family.
      Contains 1 SH3 domain.
      Contains 1 t-SNARE coiled-coil homology domain.
    • ドメインThe t-SNARE coiled-coil homology domain is necessary and sufficient for interaction with STX1A.
    • 翻訳後修飾In vitro substrate for v-Abl (By similarity). Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl.
    • 細胞内局在Cytoplasm. Nucleus. Cell projection > lamellipodium. Cell projection > filopodium. Cell projection > growth cone. Cell junction > synapse > synaptosome. Cytoplasm > cytoskeleton. Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Abelson interactor 1 antibody
      • Abi-1 antibody
      • Abi1 antibody
      • ABI1_HUMAN antibody
      • Abl binding protein 4 antibody
      • Abl interactor 1 antibody
      • Abl interactor protein 1 antibody
      • Abl-binding protein 4 antibody
      • AblBP4 antibody
      • e3B1 antibody
      • Eps8 binding protein antibody
      • Eps8 SH3 domain binding protein antibody
      • Eps8 SH3 domain-binding protein antibody
      • Eps8-binding protein antibody
      • Hssh3bp1 antibody
      • Interactor protein AblBP4 antibody
      • NAP1 antibody
      • Nap1 binding protein antibody
      • Nap1-binding protein antibody
      • Nap1BP antibody
      • Spectrin SH3 domain binding protein 1 antibody
      • Spectrin SH3 domain-binding protein 1 antibody
      • SSH3BP antibody
      see all

    Anti-SSH3BP1 (phospho Y435) antibody [EP3954] 画像

    • All lanes : Anti-SSH3BP1 (phospho Y435) antibody [EP3954] (ab109395) at 1/10000 dilution

      Lane 1 : Jurkat cell lysate, untreated
      Lane 2 : Jurkat cell lysate, treated with pervanadate

      Lysates/proteins at 10 µg per lane.

      Predicted band size : 55 kDa

    Anti-SSH3BP1 (phospho Y435) antibody [EP3954] (ab109395) 使用論文

    ab109395 has not yet been referenced specifically in any publications.

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