Anti-SRRM2 抗体 (ab122719)
Key features and details
- Rabbit polyclonal to SRRM2
- Suitable for: ICC, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-SRRM2 antibody -
製品の詳細
Rabbit polyclonal to SRRM2 -
由来種
Rabbit -
アプリケーション
適用あり: ICC, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Recombinant Protein Epitope Signature Tag antigen, corresponding to amino acids 1098 - 1203 of Human SRRM2 Isoforms 1 and 2 (Q9UQ35). Note: this sequence is missing in Isoform 3.
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ポジティブ・コントロール
- ICC: Human cell line U-2 OS; IHC-P: Human small intestine, endometrium, cerebral cortex, and skin tissues.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab122719の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC |
Use a concentration of 0.25 - 2 µg/ml.
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IHC-P | (1) |
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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ICC
Use a concentration of 0.25 - 2 µg/ml. |
IHC-P
1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA. -
組織特異性
Expressed in liver, placenta, and white blood cells. -
配列類似性
Belongs to the CWC21 family. -
翻訳後修飾
Phosphorylated upon DNA damage, probably by ATM or ATR. -
細胞内局在
Nucleus speckle. - Information by UniProt
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参照データベース
- Entrez Gene: 23524 Human
- Omim: 606032 Human
- SwissProt: Q9UQ35 Human
- Unigene: 433343 Human
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別名
- 300 kDa nuclear matrix antigen antibody
- CWC21 antibody
- KIAA0324 antibody
see all
画像
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Immunohistochemistry analysis of human small intestine tissue with ab122719 at 1/1000. Heat mediated antigen retrieval performed at pH 6.
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ab122719, at 4 ug/ml, staining SRRM2 in Human cell line U-2 OS by Immunoflouroscence.
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Immunohistochrmistry analysis of human skin tissue with ab122719 at 1/1000. Heat mediated antigen retrieval performed at pH 6.
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Immunohistochrmistry analysis of human endometrium tissue with ab122719 at 1/1000. Heat mediated antigen retrieval performed at pH 6.
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Immunohistochrmistry analysis of human cerebral cortex tissue with ab122719 at 1/1000. Heat mediated antigen retrieval performed at pH 6.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab122719 は 3 報の論文で使用されています。
- Vihola A et al. Novel mutation in TNPO3 causes congenital limb-girdle myopathy with slow progression. Neurol Genet 5:e337 (2019). PubMed: 31192305
- Tanaka H et al. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Mol Psychiatry 23:2090-2110 (2018). PubMed: 30283027
- Bai B et al. U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease. Proc Natl Acad Sci U S A 110:16562-7 (2013). IHC-FrFl ; Human . PubMed: 24023061