製品の概要

  • 製品名Anti-SRPX2 antibody
    SRPX2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SRPX2
  • 特異性ab91584 is specific for SRPX2 and will not recognize SRPX1
  • アプリケーション適用あり: ICC/IF, WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    A 16 amino acid synthetic peptide from near the amino terminus of Human SRPX2 (NP_055282).

  • ポジティブ・コントロール
    • Human lung tissue lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab91584 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 53 kDa.Can be blocked with SRPX2 peptide (ab101235).
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion in cancer cells. Increases the phosphorylation levels of FAK. May have a role in the perisylvian region, critical for language and cognitive development.
  • 組織特異性Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus and adrenal gland. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines.
  • 関連疾患Defects in SRPX2 are a cause of bilateral perisylvian polymicrogyria (BPP) [MIM:300388]. BPP is the most common form of polymicrogyria, a malformation of the cortex, in which the brain surface is irregular and the normal gyral pattern replaced by multiple small, partly fused, gyri separated by shallow sulci. BPP results in mild mental retardation, epilepsy and pseudobulbar palsy, causing difficulties with expressive speech and feeding.
    Defects in SRPX2 are a cause of rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX) [MIM:300643]. A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and mental retardation. Rolandic occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention.
  • 配列類似性Contains 1 HYR domain.
    Contains 3 Sushi (CCP/SCR) domains.
  • 細胞内局在Cytoplasm. Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BPP antibody
    • CBPS antibody
    • PMGX antibody
    • RESDX antibody
    • SRPUL antibody
    • SRPX 2 antibody
    • SRPX2 antibody
    • SRPX2_HUMAN antibody
    • Sushi repeat containing protein SRPX2 antibody
    • Sushi repeat containing protein X linked 2 antibody
    • Sushi repeat protein antibody
    • Sushi repeat-containing protein SRPX2 antibody
    see all

Anti-SRPX2 antibody 画像

  • Immunofluorescence of SRPX2 in Human lung tissue with ab91584 at 20 ug/mL.

  • Immunohistochemistry of rat lung tissue with ab91584 at 5 μg/mL.

  • Lane 1 : Anti-SRPX2 antibody (ab91584) at 1 µg/ml
    Lane 2 : Anti-SRPX2 antibody (ab91584) at 2 µg/ml

    Lane 1 : Human lung tissue lysate
    Lane 2 : Human lung tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 53 kDa

Anti-SRPX2 antibody (ab91584) 使用論文

ab91584 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab91584.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"