Rabbit polyclonal to SRGAP1
Does not crossreact with human srGAP2 or human srGAP3
Horse, Guinea pig, Cow, Dog, Chimpanzee, Rhesus monkey, Gorilla, Chinese hamster, Orangutan, Bat, Elephant
Synthetic peptide corresponding to a region between residue 979 and 1029 of human SRGAP1 (NP_065813.1)
HeLa and 293T whole cell lysates.
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Preservative: 0.09% Sodium Azide
Constituents: 0.1% BSA, Tris buffered saline
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Immunogen affinity purified
ab76926 was affinity purified using an epitope specific to SRGAP1 immobilized on solid support.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/2000 - 1/10000. Predicted molecular weight: 124 kDa.
Use at 2-5 µg/mg of lysate.
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Expressed in brain, lung, kidney, and testis.
Contains 1 FCH domain.
Contains 1 Rho-GAP domain. Contains 1 SH3 domain.
The F-BAR domain mediates oligomerization, binds membranes, and constrains plasma membrane protrusions.
Information by UniProt
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"