リコンビナント
RabMAb

Anti-SRD5A2 抗体 [EPR6281(B)] (ab124877)

製品の概要

  • 製品名
    Anti-SRD5A2 antibody [EPR6281(B)]
    SRD5A2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR6281(B)] to SRD5A2
  • アプリケーション
    適用あり: WB, IPmore details
    適用なし: Flow Cyt,ICC/IF or IHC-P
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the N-terminus of Human SRD5A2 (P31213).

  • ポジティブ・コントロール
    • LnCaP, Human testis, and PC-3 cell lysates
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab124877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).
IP 1/10 - 1/100.
  • 追加情報
    Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • ターゲット情報

    • 機能
      Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
    • 組織特異性
      Expressed in high levels in the prostate and many other androgen-sensitive tissues.
    • 関連疾患
      Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
    • 配列類似性
      Belongs to the steroid 5-alpha reductase family.
    • 細胞内局在
      Microsome membrane. Endoplasmic reticulum membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 3 oxo 5 alpha steroid 4 dehydrogenase 2 antibody
      • 3-oxo-5-alpha-steroid 4-dehydrogenase 2 antibody
      • 5 alpha SR2 antibody
      • 5 alpha-SR2 antibody
      • 5ART2 antibody
      • e II 5 alpha reductase antibody
      • EC antibody
      • MGC138457 antibody
      • Micropenis, included antibody
      • S5A2_HUMAN antibody
      • S5AR 2 antibody
      • SR type 2 antibody
      • SRD5A2 antibody
      • Steroid 5 alpha reductase 2 antibody
      • Steroid 5-alpha-reductase 2 antibody
      • Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody
      • Type II 5-alpha reductase antibody
      see all

    画像

    • All lanes : Anti-SRD5A2 antibody [EPR6281(B)] (ab124877) at 1/1000 dilution

      Lane 1 : LnCaP cell lysate
      Lane 2 : Human testis lysate
      Lane 3 : PC3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 28 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    参考文献

    ab124877 has not yet been referenced specifically in any publications.

    レビューと Q&A

    There are currently no Customer reviews or Questions for ab124877.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    登録