製品の概要

  • 製品名Anti-SRD5A2 antibody [EPR6281(B)]
    SRD5A2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR6281(B)] to SRD5A2
  • アプリケーション適用あり: WB, IPmore details
    適用なし: Flow Cyt,ICC/IF or IHC-P
  • 種交差性
    交差種: Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues near the N-terminus of Human SRD5A2 (P31213).

  • ポジティブ・コントロール
    • LnCaP, Human testis, and PC-3 cell lysates
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab124877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).
IP 1/10 - 1/100.
  • 追加情報Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • ターゲット情報

    • 機能Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
    • 組織特異性Expressed in high levels in the prostate and many other androgen-sensitive tissues.
    • 関連疾患Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
    • 配列類似性Belongs to the steroid 5-alpha reductase family.
    • 細胞内局在Microsome membrane. Endoplasmic reticulum membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 3 oxo 5 alpha steroid 4 dehydrogenase 2 antibody
      • 3-oxo-5-alpha-steroid 4-dehydrogenase 2 antibody
      • 5 alpha SR2 antibody
      • 5 alpha-SR2 antibody
      • 5ART2 antibody
      • e II 5 alpha reductase antibody
      • EC antibody
      • MGC138457 antibody
      • Micropenis, included antibody
      • S5A2_HUMAN antibody
      • S5AR 2 antibody
      • SR type 2 antibody
      • SRD5A2 antibody
      • Steroid 5 alpha reductase 2 antibody
      • Steroid 5-alpha-reductase 2 antibody
      • Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody
      • Type II 5-alpha reductase antibody
      see all

    Anti-SRD5A2 antibody [EPR6281(B)] 画像

    • All lanes : Anti-SRD5A2 antibody [EPR6281(B)] (ab124877) at 1/1000 dilution

      Lane 1 : LnCaP cell lysate
      Lane 2 : Human testis lysate
      Lane 3 : PC3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 28 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-SRD5A2 antibody [EPR6281(B)] (ab124877) 使用論文

    ab124877 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab124877.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"