Anti-SRD5A2 抗体 (ab92297)

製品の概要

• 製品名
  Anti-SRD5A2 antibody
  SRD5A2 一次抗体 製品一覧
• 製品の詳細
  Goat polyclonal to SRD5A2
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  交差が予測される動物種: Mouse, Rat, Dog, Pig, Cynomolgus monkey
• 免疫原

  Synthetic peptide:

  KMFEDYPKSRK

  witn a cysteine residue linker, corresponding to C terminal amino acids 237-247 of SRD5A2 (NP_000339.2).

  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • Human testis lysates

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• 特記事項（精製）
  Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Protein Trafficking
  • Organelle Proteins

  • Cell Biology
  • Cell Cycle
  • Cell differentiation

  • Signal Transduction
  • Metabolism
  • Vitamins / Minerals

  • Metabolism
  • Pathways and Processes
  • Cofactors, Vitamins / minerals
  • Vitamins / minerals

  • Metabolism
  • Types of disease
  • Cancer

関連製品

• Compatible Secondaries
  • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
  • Donkey Anti-Goat IgG H&L (HRP) (ab205723)

アプリケーション

ターゲット情報

• 機能
  Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
• 組織特異性
  Expressed in high levels in the prostate and many other androgen-sensitive tissues.
• 関連疾患
  Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
• 配列類似性
  Belongs to the steroid 5-alpha reductase family.
• 細胞内局在
  Microsome membrane. Endoplasmic reticulum membrane.

• Target information above from: UniProt accession P31213 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 403715 Dog
  • Entrez Gene: 6716 Human
  • Entrez Gene: 94224 Mouse
  • Entrez Gene: 397048 Pig
  • Entrez Gene: 64677 Rat
  • Omim: 607306 Human
  • SwissProt: P31213 Human
  • SwissProt: Q3UTZ9 Mouse

  • SwissProt: Q99N99 Mouse
  • SwissProt: O18765 Pig
  • SwissProt: P31214 Rat
  • Unigene: 458345 Human
  • Unigene: 38933 Mouse
  • Unigene: 9938 Rat

  see all
• 別名
  • 3 oxo 5 alpha steroid 4 dehydrogenase 2 antibody
  • 3-oxo-5-alpha-steroid 4-dehydrogenase 2 antibody
  • 5 alpha SR2 antibody

  • 5 alpha-SR2 antibody
  • 5ART2 antibody
  • e II 5 alpha reductase antibody
  • EC antibody
  • MGC138457 antibody
  • Micropenis, included antibody
  • S5A2_HUMAN antibody
  • S5AR 2 antibody
  • SR type 2 antibody
  • SRD5A2 antibody
  • Steroid 5 alpha reductase 2 antibody
  • Steroid 5-alpha-reductase 2 antibody
  • Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) antibody
  • Type II 5-alpha reductase antibody

  see all

プロトコール

• Western blot protocols