製品の概要

  • 製品名SR95531 (Gabazine)
  • 製品の詳細
    GABAA antagonist
  • 別名
    • Gabazine
  • 生理活性の詳細Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.

    Also available in simple stock solutions (ab144487) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 精製度> 98%

製品の特性

    SR95531 (Gabazine) 画像

    • A. Purkinje cell response to simulated ischemia (OGD only) in the continuous presence of the GABAA antagonist GABAzine (ab120042, 10 μM), and during subsequent block of glutamate receptors with AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM). B. Bar charts summarize the timing and magnitude of ischemia-induced glutamate currents (for both methods of simulating ischemia) with and without GABAA receptors blocked. Iglu is the magnitude of current blocked by AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM).

    SR95531 (Gabazine) (ab120042) 使用論文

    This product has been referenced in:
    • Ueno S  et al. Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. J Neurosci 17:625-34 (1997). Read more (PubMed: 8987785) »
    • Ito Y  et al. Characterization of antagonistic activity and binding properties of SR 95531, a pyridazinyl-GABA derivative, in rat brain and cultured cerebellar neuronal cells. Synapse 10:326-33 (1992). Read more (PubMed: 1585261) »
    • Wermuth CG  et al. Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of gamma-aminobutyric acid acting as selective GABA-A antagonists. J Med Chem 30:239-49 (1987). Read more (PubMed: 3027337) »

    See all 72 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"