SR144528, peripheral CB2 receptor inverse agonist (ab146185)
Key features and details
- Potent, selective peripheral CB2 receptor inverse agonist
- CAS Number: 192703-06-3
- Purity: > 98%
Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SR144528, peripheral CB2 receptor inverse agonist -
製品の詳細
Potent, selective peripheral CB2 receptor inverse agonist -
生理活性の詳細
Potent, selective peripheral CB2 receptor inverse agonist (Ki values are 0.6 and 400 nM for CB2 and CB1 receptors respectively). Decreases µ-opioid receptor expression. Enhances gastric motility in vivo.
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精製度
> 98% -
CAS 番号
192703-06-3 -
構造式
製品の特性
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体系名
5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1R,3S,4S)-2,2,4-trimethyl-3-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide
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分子量
476.05 -
分子式
C29H34ClN3O -
PubChem 登録番号
3081355 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in ethanol to 100 mM and in DMSO to 100 mM
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC1=CC=C(C=C1)CN2C(=CC(=N2)C(=O)N[C@H]3[C@]4(CC[C@H](C4)C3(C)C)C)C5=CC(=C(C=C5)Cl)C -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (7)
ab146185 は 7 報の論文で使用されています。
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- Anil SM et al. Cannabis compounds exhibit anti-inflammatory activity in vitro in COVID-19-related inflammation in lung epithelial cells and pro-inflammatory activity in macrophages. Sci Rep 11:1462 (2021). PubMed: 33446817
- Anis O et al. Cannabis-Derived Compounds Cannabichromene and ?9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization. Molecules 26:N/A (2021). PubMed: 33477303
- Peeri H et al. Specific Compositions of Cannabis sativa Compounds Have Cytotoxic Activity and Inhibit Motility and Colony Formation of Human Glioblastoma Cells In Vitro. Cancers (Basel) 13:N/A (2021). PubMed: 33916466
- Mazuz M et al. Synergistic cytotoxic activity of cannabinoids from cannabis sativa against cutaneous T-cell lymphoma (CTCL) in-vitro and ex-vivo. Oncotarget 11:1141-1156 (2020). PubMed: 32284791
- Nallathambi R et al. Anti-Inflammatory Activity in Colon Models Is Derived from ?9-Tetrahydrocannabinolic Acid That Interacts with Additional Compounds in Cannabis Extracts. Cannabis Cannabinoid Res 2:167-182 (2017). PubMed: 29082314
- Li MH et al. Compensatory Activation of Cannabinoid CB2 Receptor Inhibition of GABA Release in the Rostral Ventromedial Medulla in Inflammatory Pain. J Neurosci 37:626-636 (2017). Rat . PubMed: 28100744