Anti-SR1 抗体 (ab71983)
Key features and details
- Rabbit polyclonal to SR1
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-SR1 antibody -
製品の詳細
Rabbit polyclonal to SR1 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Mouse, Rat, Human
交差が予測される動物種: Chicken -
免疫原
Synthetic peptide (Human) sequence is amino acids 50-100 in length from Sorcin. (NP_003121).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.05% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab71983の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).
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IHC-P |
Use at an assay dependent concentration.
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特記事項 |
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WB
Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa). |
IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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機能
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. -
組織特異性
Detected in cardiac myocytes. -
配列類似性
Contains 4 EF-hand domains. -
細胞内局在
Cytoplasm. Sarcoplasmic reticulum membrane. Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels. - Information by UniProt
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参照データベース
- Entrez Gene: 420538 Chicken
- Entrez Gene: 6717 Human
- Entrez Gene: 109552 Mouse
- Entrez Gene: 683667 Rat
- Omim: 182520 Human
- SwissProt: P30626 Human
- SwissProt: Q6P069 Mouse
- Unigene: 489040 Human
see all -
別名
- 22 kDa protein antibody
- Calcium binding protein amplified in mutlidrug resistant cells antibody
- CP 22 antibody
see all
画像
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Paraffin embedded human small intestine tissue immunostained using ab71983 at 10 µg/ml.
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All lanes : Anti-SR1 antibody (ab71983) at 1 µg/ml
Lane 1 : human brain lysate
Lane 2 : human brain lysate with immunising peptide
Lane 3 : mouse brain lysate
Lane 4 : rat brain lysate
Predicted band size: 22 kDa
Observed band size: 22 kDa
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (5)
ab71983 は 5 報の論文で使用されています。
- Dekel E et al. 20S proteasomes secreted by the malaria parasite promote its growth. Nat Commun 12:1172 (2021). PubMed: 33608523
- Zhang J et al. Clinical Significance and Prognostic Value of Human Soluble Resistance-Related Calcium-Binding Protein: A Pan-Cancer Analysis. Front Med (Lausanne) 8:752619 (2021). PubMed: 34869449
- Genovese I et al. Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases. Cell Death Dis 11:861 (2020). PubMed: 33060591
- Ranum PT et al. Insights into the Biology of Hearing and Deafness Revealed by Single-Cell RNA Sequencing. Cell Rep 26:3160-3171.e3 (2019). PubMed: 30865901
- Wright MF et al. Mechanisms of intracellular calcium homeostasis in developing and mature bovine corpora lutea. Biol Reprod 90:55 (2014). WB, ICC/IF ; Cow . PubMed: 24501170