Anti-SQSTM1 / p62 抗体 (ab101266)

製品の概要

• 製品名
  Anti-SQSTM1 / p62 antibody
  SQSTM1 / p62 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to SQSTM1 / p62
• アプリケーション
  適用あり: WB, IP, IHC-Pmore details
• 種交差性
  交差種: Mouse, Human
  交差が予測される動物種: Rat, Sheep, Rabbit, Horse, Chicken, Cow, Dog, Turkey, Pig, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
• 免疫原

  Immunogen corresponds to a region within amino acids 375-425 of Human SQSTM1/ p62 (NP_003891.1)

• ポジティブ･コントロール
  • whole HeLa cells lysate

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: 0.09% Sodium Azide
  Constituents: Tris citrate/phosphate buffer, pH 7-8
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • NFkB Pathway

  • Signal Transduction
  • Protein Trafficking
  • Vesicle Transport
  • Regulation

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Polymerase associated factors
  • Pol II Transcription
  • Other

  • Cardiovascular
  • Heart
  • Autophagy
  • Autophagosome

  • Metabolism
  • Pathways and Processes
  • Metabolism processes
  • Autophagy and mitophagy
  • Autophagosome

  • Cancer
  • Cell Death
  • Autophagy
  • Autophagosome

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Immunohistochemistry kits
  • EXPOSE Rabbit specific HRP/DAB detection IHC kit (ab80437)
• Positive Controls
  • HeLa whole cell lysate (ab29545)

アプリケーション

ターゲット情報

• 機能
  Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
• 組織特異性
  Ubiquitously expressed.
• 関連疾患
  Defects in SQSTM1 are a cause of Paget disease of bone (PDB) [MIM:602080]. PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population above the age of 40 years.
• 配列類似性
  Contains 1 OPR domain.
  Contains 1 UBA domain.
  Contains 1 ZZ-type zinc finger.
• ドメイン
  The UBA domain binds specifically 'Lys-63'-linked polyubiquitin chains of polyubiquitinated substrates. Mediates the interaction with TRIM55.
  The OPR domain mediates homooligomerization and interactions with PRKCZ, PRKCI, MAP2K5 and NBR1.
  The ZZ-type zinc finger mediates the interaction with RIPK1.
• 翻訳後修飾
  Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN.
• 細胞内局在
  Cytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.

• Target information above from: UniProt accession Q13501 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 338045 Cow
  • Entrez Gene: 8878 Human
  • Entrez Gene: 18412 Mouse
  • Entrez Gene: 100172461 Orangutan
  • Entrez Gene: 113894 Rat
  • Omim: 601530 Human
  • SwissProt: Q13501 Human
  • SwissProt: Q64337 Mouse

  • SwissProt: Q5RBA5 Orangutan
  • SwissProt: O08623 Rat
  • Unigene: 709030 Human
  • Unigene: 40828 Mouse
  • Unigene: 107103 Rat

  see all
• 別名
  • A170 antibody
  • DMRV antibody
  • EBI 3 associated protein of 60 kDa antibody

  • EBI 3 associated protein p60 antibody
  • EBI3 associated protein of 60 kDa antibody
  • EBI3 associated protein p60 antibody
  • EBI3-associated protein of 60 kDa antibody
  • EBIAP antibody
  • FTDALS3 antibody
  • MGC127197 antibody
  • ORCA antibody
  • OSF-6 antibody
  • Osi antibody
  • OSIL antibody
  • Oxidative stress induced like antibody
  • p60 antibody
  • p62 antibody
  • p62B antibody
  • Paget disease of bone 3 antibody
  • PDB 3 antibody
  • PDB3 antibody
  • Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa antibody
  • Phosphotyrosine independent ligand for the Lck SH2 domain p62 antibody
  • Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody
  • PKC-zeta-interacting protein antibody
  • Protein kinase C-zeta-interacting protein antibody
  • Sequestosome 1 antibody
  • Sequestosome-1 antibody
  • SQSTM 1 antibody
  • SQSTM_HUMAN antibody
  • Sqstm1 antibody
  • STAP antibody
  • STONE14 antibody
  • Ubiquitin binding protein p62 antibody
  • Ubiquitin-binding protein p62 antibody
  • ZIP 3 antibody
  • ZIP antibody
  • ZIP3 antibody

  see all

プロトコール

• Western blot protocols
• Immunoprecipitation protocols
• Immunohistochemistry protocols