製品の概要

  • 製品名Anti-SPTLC1 antibody
    SPTLC1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SPTLC1
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Horse, Dog, Pig, Macaque Monkey, Orangutan
  • 免疫原

    Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human SPTLC1.

  • ポジティブ・コントロール
    • This antibody gave a positive signal in Human brain tissue lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab100930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).

ターゲット情報

  • 機能Serine palmitoyltransferase (SPT). The heterodimer formed with LCB2 (SPTLC2 or SPTLC3) constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SSSPTA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SSSPTA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SSSPTB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SSSPTB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
  • 組織特異性Widely expressed. Not detected in small intestine.
  • パスウェイLipid metabolism; sphingolipid metabolism.
  • 関連疾患Defects in SPTLC1 are the cause of hereditary sensory and autonomic neuropathy type 1A (HSAN1A) [MIM:162400]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN1A is an autosomal dominant axonal neuropathy with onset in the second or third decades. Initial symptoms are loss of pain, touch, heat, and cold sensation over the feet, followed by distal muscle wasting and weakness. Loss of pain sensation leads to chronic skin ulcers and distal amputations.
  • 配列類似性Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  • 細胞内局在Endoplasmic reticulum membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HSAN antibody
    • HSAN1 antibody
    • HSN1 antibody
    • LBC1 antibody
    • LCB 1 antibody
    • LCB1 antibody
    • Long chain base biosynthesis protein 1 antibody
    • MGC14645 antibody
    • Serine C palmitoyltransferase antibody
    • Serine palmitoyl CoA transferase 1 antibody
    • Serine palmitoyltransferase 1 antibody
    • Serine palmitoyltransferase long chain base subunit 1 antibody
    • Serine palmitoyltransferase subunit 1 antibody
    • Serine-palmitoyl-CoA transferase 1 antibody
    • SPT 1 antibody
    • SPT1 antibody
    • SPTC1_HUMAN antibody
    • SPTI antibody
    • SPTLC 1 antibody
    • SPTLC1 antibody
    see all

Anti-SPTLC1 antibody 画像

  • Anti-SPTLC1 antibody (ab100930) at 1 µg/ml + Human brain tissue lysate - total protein (ab29466) at 10 µg

    Secondary
    Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 53 kDa
    Observed band size : 53 kDa


    Exposure time : 4 minutes

Anti-SPTLC1 antibody (ab100930) 使用論文

ab100930 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab100930.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"