Anti-Sprouty 4/Spry-4 抗体 (ab115557)
Key features and details
- Rabbit polyclonal to Sprouty 4/Spry-4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Sprouty 4/Spry-4 antibody
Sprouty 4/Spry-4 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Sprouty 4/Spry-4 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human Sprouty 4/Spry-4 aa 300-400 (C terminal) conjugated to keyhole limpet haemocyanin.
Database link: NP_112226.2 -
ポジティブ・コントロール
- Human Heart tissue.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.424% Potassium phosphate, 0.88% Sodium chloride -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab115557の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P | (1) |
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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特記事項 |
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IHC-P
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. -
配列類似性
Belongs to the sprouty family.
Contains 1 SPR (sprouty) domain. -
ドメイン
The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles. -
細胞内局在
Cytoplasm. Cell projection > ruffle membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 81848 Human
- Omim: 607984 Human
- SwissProt: Q9C004 Human
- Unigene: 323308 Human
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別名
- Protein sprouty homolog 4 antibody
- Sprouty 4 antibody
- Sprouty homolog 4 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab115557 は 1 報の論文で使用されています。
- Brock EJ et al. Sprouty4 negatively regulates ERK/MAPK signaling and the transition from in situ to invasive breast ductal carcinoma. PLoS One 16:e0252314 (2021). PubMed: 34048471