製品の概要

  • 製品名Anti-SPR antibody
    SPR 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SPR
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 65 and 253 of Human SPR (Uniprot ID: P35270).

  • ポジティブ・コントロール
    • 293T, H1299, HeLa, HepG2 and A431 cell lysates

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab96027 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.

ターゲット情報

  • 機能Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  • 関連疾患Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
  • 配列類似性Belongs to the sepiapterin reductase family.
  • 翻訳後修飾In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
  • 細胞内局在Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • OTTHUMP00000160199 antibody
    • SDR38C1 antibody
    • Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase) antibody
    • Sepiapterin reductase antibody
    • Short chain dehydrogenase/reductase family 38C, member 1 antibody
    • SPR antibody
    • SPRE_HUMAN antibody
    see all

Anti-SPR antibody 画像

  • Anti-SPR antibody (ab96027) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 28 kDa

Anti-SPR antibody (ab96027) 使用論文

ab96027 has not yet been referenced specifically in any publications.

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There are currently no Abreviews or Questions for ab96027.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"