製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SPR
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide conjugated to KLH, between C terminal amino acids 232-261 of Human SPR.

  • ポジティブ・コントロール
    • Mouse liver tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab103353 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/1000. Predicted molecular weight: 28 kDa.

ターゲット情報

  • 機能
    Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
  • 関連疾患
    Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD) [MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia and spasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonin deficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures.
  • 配列類似性
    Belongs to the sepiapterin reductase family.
  • 翻訳後修飾
    In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
  • 細胞内局在
    Cytoplasm.
  • Information by UniProt
  • 参照データベース
  • 別名
    • OTTHUMP00000160199 antibody
    • SDR38C1 antibody
    • Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase) antibody
    • Sepiapterin reductase antibody
    • Short chain dehydrogenase/reductase family 38C, member 1 antibody
    • SPR antibody
    • SPRE_HUMAN antibody
    see all

画像

  • Anti-SPR antibody (ab103353) at 1/1000 dilution + Mouse liver tissue lysate at 35 µg

    Secondary
    Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

    Predicted band size : 28 kDa

    Blocking/Dilution buffer: 5% NFDM/TBST.

プロトコール

参考文献

ab103353 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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