製品の概要

  • 製品名Anti-SPINK5 antibody
    SPINK5 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to SPINK5
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the N terminal region of Human SPINK5.

  • ポジティブ・コントロール
    • A2058 cell line lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファーPreservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)This antibody is purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab92582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 121 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
    • 組織特異性Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate.
    • 関連疾患Defects in SPINK5 are the cause of Netherton syndrome (NETH) [MIM:256500]. NETH is an autosomal recessive congenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical features are ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopic dermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremic dehydration.
    • 配列類似性Contains 15 Kazal-like domains.
    • ドメインContains at least one active inhibitory domain for trypsin (domain 6).
    • 翻訳後修飾Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases.
    • 細胞内局在Secreted.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Hemofiltrate peptide HF7665 antibody
      • ISK5_HUMAN antibody
      • LEKTI antibody
      • Lympho-epithelial Kazal-type-related inhibitor antibody
      • Lymphoepithelial Kazal type related inhibitor antibody
      • NETS antibody
      • NS antibody
      • Serine peptidase inhibitor Kazal type 5 antibody
      • SPINK5 antibody
      • VAKTI antibody
      see all

    Anti-SPINK5 antibody 画像

    • Anti-SPINK5 antibody (ab92582) at 1/100 dilution + A2058 cell line lysate at 35 µg

      Predicted band size : 121 kDa

    Anti-SPINK5 antibody (ab92582) 使用論文

    ab92582 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab92582.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"