Anti-SPHK1 抗体 (ab61148)
Key features and details
- Rabbit polyclonal to SPHK1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-SPHK1 antibody
SPHK1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to SPHK1 -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human SPHK1 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).
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ポジティブ・コントロール
- Adrenal tissue (pheochromocytes).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.70
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab61148の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
Use a concentration of 10 µg/ml.
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特記事項 |
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IHC-P
Use a concentration of 10 µg/ml. |
ターゲット情報
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機能
Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. -
組織特異性
Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. -
配列類似性
Contains 1 DAGKc domain. - Information by UniProt
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参照データベース
- Entrez Gene: 8877 Human
- Omim: 603730 Human
- SwissProt: Q9NYA1 Human
- Unigene: 68061 Human
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別名
- SK 1 antibody
- SK1 antibody
- Sphingosine kinase 1 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab61148 は 5 報の論文で使用されています。
- Wu X et al. Inhibition of SphK1/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction. Comput Math Methods Med 2022:5985375 (2022). PubMed: 35872958
- Shen W et al. LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1. Cell Cycle 20:829-838 (2021). PubMed: 33849377
- Reichmann MT et al. Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131:N/A (2021). PubMed: 34128839
- Chen J et al. Deletion of sphingosine kinase 1 inhibits liver tumorigenesis in diethylnitrosamine-treated mice. Oncotarget 9:15635-15649 (2018). PubMed: 29643998
- Chen MH et al. Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. Oncotarget 6:23594-608 (2015). PubMed: 26090720