製品の概要

  • 製品名Anti-SP100 antibody
    SP100 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to SP100
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY DIVFKHFKRN KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRN, corresponding to amino acids 1-99 of Human SP100

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab58206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能May play a role in the control of gene expression.
    • 組織特異性Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
    • 配列類似性Contains 2 HMG box DNA-binding domains.
      Contains 1 HSR domain.
      Contains 1 SAND domain.
    • ドメインThe HSR domain is important for the nuclear body targeting as well as for the dimerization.
      Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
    • 翻訳後修飾Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting.
    • 細胞内局在Nucleus > PML body. Found in the nuclear body, also known as nuclear domain 10 (ND10), PML oncogenic domain (POD), nuclear dots (ND) and KR body. The nuclear body is a nucleoplasmic structure of punctate shape, which varies in size and number. Induction by interferon and may be cell cycle stages modulate the subnuclear localization of the isoforms.
    • Information by UniProt
    • 参照データベース
    • 別名
      • DKFZp686E07254 antibody
      • FLJ00340 antibody
      • FLJ34579 antibody
      • Lysp100b antibody
      • Nuclear antigen Sp100 antibody
      • Nuclear autoantigen Sp 100 antibody
      • Nuclear autoantigen Sp-100 antibody
      • Nuclear autoantigen Sp100 antibody
      • Nuclear dot associated Sp100 protein antibody
      • Nuclear dot-associated Sp100 protein antibody
      • SP 100 antibody
      • SP100 antibody
      • SP100 HMG nuclear autoantigen antibody
      • SP100 nuclear antigen antibody
      • SP100_HUMAN antibody
      • Speckled 100 kDa antibody
      see all

    Anti-SP100 antibody 画像

    • Western blot against tagged recombinant protein immunogen using ab58206 SP100 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-SP100 antibody (ab58206) 使用論文

    This product has been referenced in:
    • Schmeisser H  et al. Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene. J Virol 84:10671-80 (2010). WB ; Human . Read more (PubMed: 20686046) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"