製品の概要

  • 製品名
    Anti-SOS1 antibody [AF3F11]
    SOS1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [AF3F11] to SOS1
  • アプリケーション
    適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Other Immunogen Type corresponding to Human SOS1 (C terminal).
    Database link: Q07889

  • ポジティブ・コントロール
    • HepG2 cell lysate, HeLa cell lysate, MOLT4 cell lysate, NIH3T3 cell lysate and PC12 cell lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab82429 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 2 µg/ml. Predicted molecular weight: 152 kDa.
ELISA Use at an assay dependent concentration.

ターゲット情報

  • 機能
    Promotes the exchange of Ras-bound GDP by GTP.
  • 組織特異性
    Expressed in gingival tissues.
  • 関連疾患
    Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common.
    Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common.
  • 配列類似性
    Contains 1 DH (DBL-homology) domain.
    Contains 1 N-terminal Ras-GEF domain.
    Contains 1 PH domain.
    Contains 1 Ras-GEF domain.
  • Information by UniProt
  • 参照データベース
  • 別名
    • alternate SOS1 antibody
    • GF1 antibody
    • GGF1 antibody
    • GINGF antibody
    • gingival fibromatosis antibody
    • gingival fibromatosis hereditary 1 antibody
    • Guanine nucleotide exchange factor antibody
    • HGF antibody
    • NS4 antibody
    • Son of sevenless homolog 1 (Drosophila) antibody
    • Son of sevenless homolog 1 antibody
    • SOS Ras/Rac guanine nucleotide exchange factor 1 antibody
    • SOS-1 antibody
    • Sos1 antibody
    • SOS1_HUMAN antibody
    see all

画像

  • All lanes : Anti-SOS1 antibody [AF3F11] (ab82429) at 500

    Lane 1 : HeLa cell lysate
    Lane 2 : MOLT4 cell lysate
    Lane 3 : PC12 cell lysate
    Lane 4 : NIH3T3 cell lysate


    Predicted band size : 152 kDa
  • All lanes : Anti-SOS1 antibody [AF3F11] (ab82429) at 1/1000 dilution

    Lane 1 : HeLa cell lysates
    Lane 2 : MOLT4 cell lysates
    Lane 3 : HepG2 cell lysates
    Lane 4 : NIH3T3 cell lysates
    Lane 5 : PC12 cell lysates


    Predicted band size : 152 kDa
    Observed band size : 152 kDa

プロトコール

参考文献

ab82429 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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