Anti-SorLA/SORL1 抗体 (ab22814)
Key features and details
- Goat polyclonal to SorLA/SORL1
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-SorLA/SORL1 antibody
SorLA/SORL1 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to SorLA/SORL1 -
由来種
Goat -
アプリケーション
適用あり: ICC/IFmore details -
種交差性
交差種: Human
交差が予測される動物種: Rat, Rabbit, Cow, Dog -
免疫原
Synthetic peptide corresponding to Human SorLA/SORL1 aa 2203-2214 (C terminal).
Sequence:TGFSDDVPMVIA
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ポジティブ・コントロール
- Mouse brain lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
特記事項(精製)
ab22814 is purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab22814の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
ICC/IF |
Use a concentration of 10 µg/ml.
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特記事項 |
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ICC/IF
Use a concentration of 10 µg/ml. |
ターゲット情報
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機能
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. -
組織特異性
Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals. -
配列類似性
Belongs to the SORL1 family.
Contains 5 BNR repeats.
Contains 1 EGF-like domain.
Contains 6 fibronectin type-III domains.
Contains 11 LDL-receptor class A domains.
Contains 5 LDL-receptor class B repeats. -
翻訳後修飾
The propeptide removed in the N-terminus may be cleaved by furin or homologous proteases. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6653 Human
- Entrez Gene: 300652 Rat
- Omim: 602005 Human
- SwissProt: Q92673 Human
- SwissProt: Q9R0N2 Rat
- Unigene: 368592 Human
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別名
- C11orf32 antibody
- FLJ21930 antibody
- FLJ39258 antibody
see all
画像
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Immunocytochemistry/ Immunofluorescence of HepG2 staining SorLA/SORL1 using ab22814 at 10 μg/ml followed by Alexa Fluor 488 secondary antibody 2 μg/ml
The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 μg/ml) followed by Alexa Fluor 488 secondary antibody (2 μg/ml).
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Immunocytochemistry/ Immunofluorescence of A431 staining SorLA/SORL1 using ab22814 at 10 μg/ml followed by Alexa Fluor 488 secondary antibody 2 μg/ml
The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 μg/ml) followed by Alexa Fluor 488 secondary antibody (2 μg/ml).
データシートおよび資料
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Datasheet download
参考文献 (0)
ab22814 は論文での使用が確認できていません。