製品の概要

  • 製品名Anti-SORBS2 antibody
    SORBS2 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to SORBS2
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length (aa 1-1100) human SORBS2 protein (NP_066547.1).

  • ポジティブ・コントロール
    • HepG2 cells; SORBS2 transfected 293T cell lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • バッファーPreservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab73444 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 124 kDa (predicted molecular weight: 124 kDa).
ICC/IF Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
  • 組織特異性Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. In the pancreas, mainly expressed in acinar cells, duct cells and all cell types in islets (at protein level). Tends to be down-regulated in pancreatic adenocarcinomas ans metastases.
  • 配列類似性Contains 3 SH3 domains.
    Contains 1 SoHo domain.
  • ドメインThe first 2 SH3 domains are required for WASF1-binding. All 3 SH3 domains can bind independently to PTPN12.
  • 翻訳後修飾Ubiquitinated by CBL.
    Dephosphorylated by PTPN12.
  • 細胞内局在Cytoplasm, perinuclear region. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium. Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Arg binding protein 2 antibody
    • Arg-binding protein 2 antibody
    • Arg/Abl interacting protein 2 antibody
    • Arg/Abl interacting protein antibody
    • Arg/Abl-interacting protein 2 antibody
    • ArgBP2 antibody
    • KIAA0777 antibody
    • PRO0618 antibody
    • sorbin and SH3 domain containing 2 antibody
    • Sorbin and SH3 domain-containing protein 2 antibody
    • Sorbin antibody
    • Sorbs2 antibody
    • SRBS2_HUMAN antibody
    see all

Anti-SORBS2 antibody 画像

  • ab73444 at 10µg/ml staining SORBS2 in HepG2 cells by Immunofluorescence.
  • All lanes : Anti-SORBS2 antibody (ab73444) at 1/500 dilution

    Lane 1 : SORBS2 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 124 kDa
    Observed band size : 124 kDa

Anti-SORBS2 antibody (ab73444) 使用論文

ab73444 has not yet been referenced specifically in any publications.

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