Anti-soluble TNF Receptor I 抗体 (ab9979)

製品の概要

  • 製品名Anti-soluble TNF Receptor I antibody
    Soluble TNF Receptor I 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to soluble TNF Receptor I
  • アプリケーション適用あり: WB, ELISA, Neutralisingmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Highly pure (>98%) recombinant hsTNF-R1 (human soluble Tumor Necrosis Factor Receptor-1)

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab9979 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.1 - 0.2 µg/ml.
ELISA Use a concentration of 0.5 µg/ml.
Neutralising Use at an assay dependent dilution. To yield one-half maximal inhibition [ND50] of the biological activity of hsTNF-R1 (0.3 µg/ml), a concentration of 0.9 - 1.1 µg/ml of this antibody is required.

ターゲット情報

  • 関連性TNF RI (CD120a) is a 55 kDa transmembrane glycoprotein that is expressed by virtually all nucleated mammalian cells. Among the numerous cells known to express TNF RI are hepatocytes, monocytes and neutrophils, cardiac muscle cells, endothelial cells, and CD34+ hematopoietic progenitors. Both TNF alpha and TNF beta bind to TNF RI. Soluble TNF alpha binds with a Kda in the range of 20-60 pM, while TNF beta binds with a Kda equal to 650 pM. TNF RI relative to TNF RII seems to be the more physiologically relevant receptor, whereas TNF R2 appears to play a direct role in only a limited number of TNF responses. Soluble TNF RI, which blocks TNF alpha activity, has been identified in both urine and blood (1-3 ng/mL). Serum levels of sTNF receptors increase dramatically in certain pathological situations.
  • 細胞内局在Cytoplasmic
  • 参照データベース
  • 別名
    • CD120a antibody
    • TBP1 antibody
    • TNFR1 antibody
    • TNFR55 antibody
    • TNFRSF1A antibody
    • Tumor necrosis factor receptor 1 antibody
    see all

Anti-soluble TNF Receptor I antibody (ab9979) 使用論文

ab9979 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab9979.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"