機能Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
配列類似性Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
翻訳後修飾Phosphorylated by PKA, which inhibits activity.
細胞内局在Membrane. In intestinal epithelial cells, localizes to the ileal brush border.