製品の概要

  • 製品名Anti-SOCS7 antibody
    SOCS7 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to SOCS7
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    C-DAGRKPKLTRTQS

    , corresponding to internal sequence amino acids 260 - 272 of Human SOCS7.

  • ポジティブ・コントロール
    • Daudi lysate.

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • 特記事項(精製)ab80603 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab80603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報Peptide ELISA: antibody detection limit dilution 1/32000
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 63 kDa (predicted molecular weight: 63 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    • 組織特異性Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
    • パスウェイProtein modification; protein ubiquitination.
    • 配列類似性Contains 1 SH2 domain.
      Contains 1 SOCS box domain.
    • ドメインThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
    • 細胞内局在Cytoplasm. Cell membrane. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Ash and phospholipase C gamma-binding protein antibody
      • NAP 4 antibody
      • NAP 4 Fragment antibody
      • NAP-4 antibody
      • NAP4 antibody
      • Nck antibody
      • Nck Ash and phospholipase C binding protein antibody
      • Nck Ash and phospholipase C gamma binding protein antibody
      • Nck associated protein 4 antibody
      • Nck-associated protein 4 antibody
      • NCKAP4 antibody
      • SH2 domain containing SOCS box protein antibody
      • SOCS 7 antibody
      • SOCS-7 antibody
      • SOCS4 antibody
      • SOCS6 antibody
      • Socs7 antibody
      • SOCS7_HUMAN antibody
      • Suppressor of cytokine signaling 7 antibody
      see all

    Anti-SOCS7 antibody 画像

    • Anti-SOCS7 antibody (ab80603) at 1 µg/ml + Daudi lysate (in RIPA buffer) at 35 µg

      Predicted band size : 63 kDa
      Observed band size : 63 kDa
      Additional bands at : 28 kDa. We are unsure as to the identity of these extra bands.

    Anti-SOCS7 antibody (ab80603) 使用論文

    ab80603 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab80603.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"