追加情報WB: 1/1000. This antibody was tested against the recombinant protein fragment used as immunogen. We have no data on the detection of endogenous protein.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
機能Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
組織特異性Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
パスウェイProtein modification; protein ubiquitination.
ドメインThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
細胞内局在Cytoplasm. Cell membrane. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
Ash and phospholipase C gamma-binding protein antibody
NAP 4 antibody
NAP 4 Fragment antibody
Nck Ash and phospholipase C binding protein antibody
Nck Ash and phospholipase C gamma binding protein antibody
Nck associated protein 4 antibody
Nck-associated protein 4 antibody
SH2 domain containing SOCS box protein antibody
SOCS 7 antibody
Suppressor of cytokine signaling 7 antibody
Anti-SOCS7 antibody (ab13951) 使用論文
This product has been referenced in:
Pereira CP et al. Transcriptome analysis revealed unique genes as targets for the anti-inflammatory action of activated protein C in human macrophages. PLoS One5:e15352 (2010).
Read more (PubMed: 20976180) »