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Synthetic peptide corresponding to C-terminus of human/ mouse SOCS 4.
Accumulating evidence demonstrates that cytokine receptorsignaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an Nterminalregion of variable length and amino acidcomposition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of aclassical negative feed back loop that regulates cytokinesignal transduction via a STAT-induced transcriptionalmechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. Within the SOCS subfamily, SOCS 4, SOCS 5, SOCS 6 and SOCS 7 remain poorly understood. On the basis ofstructural considerations, it would be expected if SOCS 4 and SOCS 7, like SOCS 1, SOCS 2, SOCS 3 and CIS, acted tonegatively regulated signal transduction, but not surewhich specific cytokine is involved.
Our Abpromise guarantee covers the use of ab3694 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use at an assay dependent concentration.|
|WB||Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 50 kDa).|
|IP||Use at an assay dependent concentration. use at a concentration of 3.0 - 5.0 µg / extract from 107 cells.|
|ELISA||Use a concentration of 0.1 - 1 µg/ml.|
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