製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to SOCS4
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Cow, Pig
  • 免疫原

    Synthetic peptide:

    SKVRVLRIDAPEQQ

    , corresponding to C terminal amino acids 426-439 of Human SOCS7.

  • 特記事項
    Principal Names – SOCS7; SOCS4; suppressor of cytokine signaling 7; SH2 domain containing SOCS box protein. Official Gene Symbol - SOCS7. GenBank Accession Number – NP_543143. LocusLink ID - 122809 (human). Gene Ontology terms - intracellular signaling cascade; regulation of cell growth.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, 5mg/ml Tris, pH 7.3
  • Concentration information loading...
  • 精製度
    IgG fraction
  • 特記事項(精製)
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab3607 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml.
IHC-P Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • パスウェイ
    Protein modification; protein ubiquitination.
  • 配列類似性
    Contains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • ドメイン
    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CIS4 antibody
    • Cish4 antibody
    • Cytokine inducible SH2 protein 4 antibody
    • DKFZp686J1568 antibody
    • HSPC060 antibody
    • SH2 domain containing SOCS box protein antibody
    • SOCS-4 antibody
    • SOCS-7 antibody
    • SOCS4 antibody
    • SOCS4_HUMAN antibody
    • SOCS6 antibody
    • SOCS7 antibody
    • SSI4 antibody
    • STAI4 antibody
    • STAT induced STAT inhibitor 4 antibody
    • STAT4 antibody
    • STATI4 antibody
    • Suppressor of cytokine signaling 4 antibody
    • Suppressor of cytokine signaling 7 antibody
    see all

画像

  • ab3607 at a 2µg/ml concentration staining ~50 kDa SOCS 7 in NIH-3T3 cell lysate (RIPA buffer, 30µg total protein per lane) by Western blot. 1 hour incubation, ECL detection.
  • ab3607 (3.8µg/ml) staining of paraffin embedded Human Pancreas shows cytoplasm staining on select beta cells in islet of Langerhans. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

参考文献

ab3607 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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