リコンビナント
RabMAb

Anti-SOCS2 抗体 [EPR2588(2)] (ab109245)

製品の概要

  • 製品名
    Anti-SOCS2 antibody [EPR2588(2)]
    SOCS2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit monoclonal [EPR2588(2)] to SOCS2
  • アプリケーション
    適用あり: WB, IP, ICC/IFmore details
    適用なし: Flow Cyt or IHC-P
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    A synthetic peptide corresponding to residues near the N-terminus of Human SOCS2

  • ポジティブ・コントロール
    • MCF7 cell lysate, NCCIT cell lysate, K562 cell lysate; HeLa cells
  • 特記事項

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab109245 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000 - 1/10000. Predicted molecular weight: 22 kDa.
IP 1/10 - 1/100.
ICC/IF 1/100 - 1/250.
  • 追加情報
    Is unsuitable for Flow Cyt or IHC-P.
  • ターゲット情報

    • 機能
      SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    • 組織特異性
      High expression in heart, placenta, lung, kidney and prostate.
    • パスウェイ
      Protein modification; protein ubiquitination.
    • 配列類似性
      Contains 1 SH2 domain.
      Contains 1 SOCS box domain.
    • ドメイン
      The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CIS 2 antibody
      • CIS-2 antibody
      • CIS2 antibody
      • Cish 2 antibody
      • Cish2 antibody
      • Cytokine inducible SH2 protein 2 antibody
      • Cytokine-inducible SH2 protein 2 antibody
      • SOCS 2 antibody
      • SOCS-2 antibody
      • Socs2 antibody
      • SOCS2_HUMAN antibody
      • SSI 2 antibody
      • SSI-2 antibody
      • SSI2 antibody
      • STAT induced STAT inhibitor 2 antibody
      • STAT-induced STAT inhibitor 2 antibody
      • STATI 2 antibody
      • STATI2 antibody
      • Suppressor of cytokine signaling 2 antibody
      see all

    画像

    • Immunofluorescent staining of HeLa cells using ab109245 at 1/100 dilution.
    • All lanes : Anti-SOCS2 antibody [EPR2588(2)] (ab109245) at 1/1000 dilution

      Lane 1 : MCF7 cell lysate
      Lane 2 : NCCIT cell lysate
      Lane 3 : K562 cell lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 22 kDa

    参考文献

    ab109245 has not yet been referenced specifically in any publications.

    レビューと Q&A

    Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

    I have issued a free of charge replacement, ab92847.

    To check the status of the order ...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    登録