製品の概要

  • 製品名Anti-SNX17 antibody
    SNX17 一次抗体 製品一覧
  • 製品の詳細
    Mouse polyclonal to SNX17
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-470 of Human SNX17

  • ポジティブ・コントロール
    • SNX17 transfected 293T cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein A purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab67599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).

ターゲット情報

  • 機能Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
  • 配列類似性Belongs to the sorting nexin family.
    Contains 1 PX (phox homology) domain.
    Contains 1 Ras-associating domain.
  • ドメインThe PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.
    The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.
  • 細胞内局在Cytoplasm. Early endosome. Cytoplasmic vesicle membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Similar to a putative C elegans gene encoded in cosmid F17H10 antibody
    • Snx17 antibody
    • SNX17_HUMAN antibody
    • Sorting nexin 17 antibody
    • Sorting nexin-17 antibody
    see all

Anti-SNX17 antibody 画像

  • All lanes : Anti-SNX17 antibody (ab67599) at 1/500 dilution

    Lane 1 : SNX17 transfected 293T lysate
    Lane 2 : Non transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 53 kDa
    Observed band size : 53 kDa

Anti-SNX17 antibody (ab67599) 使用論文

ab67599 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab67599.
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