製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SNX17
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 52-82 of Human SNX17 (NP_055563.1).

  • ポジティブ・コントロール
    • 293 cell line lysate

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • バッファー
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 特記事項(精製)
    ab124232 was purified through a protein A column, followed by peptide affinity purification.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab124232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100 - 1/500. Predicted molecular weight: 53 kDa.

ターゲット情報

  • 機能
    Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
  • 配列類似性
    Belongs to the sorting nexin family.
    Contains 1 PX (phox homology) domain.
    Contains 1 Ras-associating domain.
  • ドメイン
    The PX domain mediates specific binding to phosphatidylinositol 3-phosphate (PtdIns(P3)). Required for association with endosomes.
    The PTB-like F3 module within the FERM-like domain mediates cargo recognition via their NPxY sequences, while the F1 module (Ras-associating) is responsible for interaction with membrane-bound HRAS.
  • 細胞内局在
    Cytoplasm. Early endosome. Cytoplasmic vesicle membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Similar to a putative C elegans gene encoded in cosmid F17H10 antibody
    • Snx17 antibody
    • SNX17_HUMAN antibody
    • Sorting nexin 17 antibody
    • Sorting nexin-17 antibody
    see all

Anti-SNX17 antibody 画像

  • Anti-SNX17 antibody (ab124232) at 1/100 dilution + 293 cell line lysate at 35 µg

    Predicted band size : 53 kDa

プロトコール

Anti-SNX17 antibody (ab124232) 使用論文

ab124232 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab124232.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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