製品の概要

  • 製品名SNX 482
  • 製品の詳細
    R-Type Ca2+ (Cav2.3) channel blocker
  • 生理活性の詳細Peptide toxin that naturally occurs in the venom of the spider Hysterocrates gigas. Selectively blocks Cav2.3 (α1E, R-type) channels in a voltage dependent manner (IC50 = 15-30 nM). At higher concentrations, also blocks Cav2.1 channels in chromaffin cells.
  • 精製度> 96%

製品の特性

    SNX 482 (ab120259) 使用論文

    This product has been referenced in:
    • Arroyo G  et al. SNX482 selectively blocks P/Q Ca2+ channels and delays the inactivation of Na+ channels of chromaffin cells. Eur J Pharmacol 475:11-8 (2003). Read more (PubMed: 12954354) »
    • Bourinet E  et al. Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels. Biophys J 81:79-88 (2001). Read more (PubMed: 11423396) »
    • Newcomb R  et al. Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry 37:15353-62 (1998). Read more (PubMed: 9799496) »

    See 1 Publication for this product

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    Vielen Dank für Ihre Anfrage.

    Ich kann bestätigen, dass SNX482 Asc-259 (ab120259) bei -20C gelagert werden sollte auch wenn es gelöst ist.
    Generell empfehlen wir, wenn möglich, Lösungen immer frisch anzusetzen.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"