製品の概要

  • 製品名
  • 製品の詳細
    Chicken polyclonal to SNAPIN
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide, corresponding to amino acids 31-136 of Human SNAPIN

  • ポジティブ・コントロール
    • Brain tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab37496 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000. Detects a band of approximately 70 kDa for the fusion protein (predicted molecular weight for the native protein: 15 kDa).

ターゲット情報

  • 機能
    May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells.
  • 組織特異性
    Expressed in male germ cells of adult testis (at protein level).
  • 配列類似性
    Belongs to the SNAPIN family.
  • 発生段階
    Expressed in germ cells of 22-week prenatal testis.
  • 細胞内局在
    Cytoplasm. Membrane. Cytoplasmic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome. Cytoplasm > perinuclear region. May be cytoplasmic and peripheral membrane bound or anchored to the vesicular membrane through an N-terminal signal anchor (By similarity). Co-localizes with NANOS1 and PUM2 in the perinuclear region of germ cells.
  • Information by UniProt
  • 参照データベース
  • 別名
    • OTTHUMP00000035157 antibody
    • SNAP associated protein antibody
    • SNAP-25-binding protein antibody
    • SNAP-associated protein antibody
    • SNAP25BP antibody
    • SNAPAP antibody
    • Snapin antibody
    • SNAPN_HUMAN antibody
    • SNARE associated protein snapin antibody
    • SNARE-associated protein Snapin antibody
    • Synaptosomal associated protein 25 binding protein antibody
    • Synaptosomal-associated protein 25-binding protein antibody
    see all

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プロトコール

参考文献

This product has been referenced in:
  • Zhang Q  et al. E3 ubiquitin ligase RNF13 involves spatial learning and assembly of the SNARE complex. Cell Mol Life Sci 70:153-65 (2013). Read more (PubMed: 22890573) »
  • Blandin G  et al. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Skelet Muscle 3:3 (2013). WB . Read more (PubMed: 23414517) »

See all 3 Publications for this product

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