製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to SMUBP2
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Guinea pig, Cow, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N-terminal amino acids 15-64 (QLLELERDAE VEERRSWQEH SSLRELQSRG VCLLKLQVSS QRTGLYGQRL) of Mouse SMUBP2 (NP_033238).

  • ポジティブ・コントロール
    • Mouse heart lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111364 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 109 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能
    5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV.
  • 組織特異性
    Expressed in all tissues examined.
  • 関連疾患
    Defects in IGHMBP2 are the cause of distal hereditary motor neuronopathy type 6 (HMN6) [MIM:604320]; also known as spinal muscular atrophy distal autosomal recessive 1 (DSMA1) or spinal muscular atrophy with respiratory distress 1 (SMARD1). Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. The most prominent symptoms of HMN6 are severe respiratory distress resulting from diaphragmatic paralysis with eventration shown on chest x-ray and predominant involvement of the upper limbs and distal muscles.
  • 配列類似性
    Belongs to the DNA2/NAM7 helicase family.
    Contains 1 AN1-type zinc finger.
    Contains 1 R3H domain.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在
    Nucleus. Cytoplasm. Cell projection > axon. Colocalizes with the traslation initiation factor EIF4G2.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AEP antibody
    • Antifreeze enhancer binding protein antibody
    • ATP-dependent helicase IGHMBP2 antibody
    • Cardiac transcription factor 1 antibody
    • Cardiac transcription factor1 antibody
    • CATF 1 antibody
    • CATF1 antibody
    • CMT2S antibody
    • DNA-binding protein SMUBP-2 antibody
    • GF-1 antibody
    • Glial factor 1 antibody
    • HCSA antibody
    • HMN 6 antibody
    • HMN6 antibody
    • IGHMBP 2 antibody
    • Ighmbp2 antibody
    • Immunoglobulin mu binding protein 2 antibody
    • Immunoglobulin mu binding protein2 antibody
    • Immunoglobulin mu-binding protein 2 antibody
    • Immunoglobulin S mu binding protein 2 antibody
    • Immunoglobulin S mu binding protein2 antibody
    • RIPE3 b1 antibody
    • RIPE3b 1 antibody
    • RIPE3b1 antibody
    • SMARD 1 antibody
    • SMARD1 antibody
    • SMBP2_HUMAN antibody
    • SMUBP 2 antibody
    • SMUBP2 antibody
    • ZFAND7 antibody
    • zinc finger, AN1 type domain 7 antibody
    see all

画像

  • Anti-SMUBP2 antibody (ab111364) at 1 µg/ml + Mouse heart lysate at 10 µg

    Predicted band size : 109 kDa

プロトコール

参考文献

ab111364 has not yet been referenced specifically in any publications.

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